Title:Role of Epigenetics and Oxidative Stress in Gliomagenesis
Volume: 16
Issue: 10
Author(s): Yesennia Sanchez-Perez, Ernesto Soto-Reyes, Claudia M. Garcia-Cuellar, Bernardo Cacho-Diaz, Abel Santamaria and Edgar Rangel-Lopez*
Affiliation:
- National Institute of Neurology and Neurosurgery, Laboratory of Excitatory Amino Acids. Av. Insurgentes Sur #3877 Col. La Fama. Delegacion Tlalpan, C.P. 14269 Mexico City,United States
Keywords:
Brain tumors, clinical trials, epigenetics, glioma, malignant, oxidative stress.
Abstract: Background & Objective: Gliomas constitute 81% of malignant brain tumors and exhibit a
poor prognosis. Two main events involved in the progression of gliomas are the deregulation of genes
via genetic events and the cellular damage resulting from the formation of reactive oxygen species
(ROS). In gliomas, epigenetic abnormalities implicated in the deregulation of deoxyribonucleic acid
(DNA) methylation, nucleosome rearrangement, and acetylation of histones, have been depicted. The
overproduction of ROS has been implicated in the promotion of these modifications.
Conclusion: In this review, we discuss the epigenetic mechanisms and oxidative events that impact
gene silencing and its association with the establishment and development of gliomas. Some of these
epigenetic marks, or their related proteins, are under investigation for their potential use as biomarkers
in clinical trials to propose personalized therapies for patients with glioblastoma.
