Title:Antiplatelet Potential of Plant-Derived Glycosides as Possible Lead Compounds
Volume: 19
Issue: 10
Author(s): Haroon Khan*, Aini Pervaiz, Mohammad A. Kamal and Seema Patel
Affiliation:
- Department of Pharmacy, Abdul Wali Khan University, Mardan 23200,Pakistan
Keywords:
Medicinal plants, glycosides, antiplatelet, possible mechanisms, safety profile, lead compounds.
Abstract: Background: Blood platelets are crucial for maintaining hemostasis and several events in the woundhealing.
However, platelet up-regulation leads to the development and the complications of several cardiovascular
diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as
aspirin, warfarin and other drugs. since a long time. But some adverse reactions like aspirin resistance and bleed
disorders cause patient incompliance and reduce their therapeutic potential. Thus, the search for potent and safer
antiplatelet agents is of great interest.
Methods: Various search engines such as Google, GoogleScholar, PubMed and ScienceDirect were used for the
search of antiplatelet glycosides. All peered review journals were considered in the review.
Results: Glycoside is a class of naturally-occurring organic compounds that are frequently found in the plant kingdom.
Similarly, platelet aggregation beyond the purpose of hemostasis is the underlying cause of blood clottingrelated
diseases. The results showed strong potential of plant derived glycosides in various preclinical studies.
Conclusions: This review presents a thorough understanding of plant-derived glycosides as antiplatelet agents with a
possible mechanism of action based on the existing literature. In addition, this review discusses the possibility of
formulating antiplatelet medications from plant glycosides with strong safety profile. On the basis of strong finding,
clinical studies are recommended to ascertain their therapeutic utility.
