Title:Neuroprotective Effects of Flavonoid Compounds on Neuronal Death Associated to Alzheimer’s Disease
Volume: 26
Issue: 27
关键词:
抗氧化剂，细胞凋亡，线粒体，神经变性，多酚，阿尔茨海默氏病。
摘要: Alzheimer’s disease is an increasing neurodegenerative pathology related to
age in many societies. Some aspects of the disease are related to the loss of neuronal cells
derived by the formation of extracellular neuritic plaques and the appearance of intracellular
neurofibrillary tangles, altogether generating an inflammatory and oxidative status.
The accumulation of amyloids in cells induces the activation of the apoptotic cascade
which implies caspases activation. Alzheimer’s disease is treated with acetylcholine esterase
inhibitors, although their effects are still far away to reduce or eliminate the problems
associated with the pathology. The lack of effective treatment has led to the search
for new therapeutic alternatives based on natural products. Flavonoids comprise a group
of phenolic compounds that have gained great interest since they present great diversity of
biological activities. In the present work, we review the potential uses of flavonoids and
the proposed mechanisms of action as a new therapeutic strategy in neurological cell
death associated with Alzheimer’s disease.
