Title:Systemic Administration of Antipsychotic Asenapine Pre or Postnatal does not Induce Anxiety-like Behaviors in Mice
Volume: 16
Issue: 10
Author(s): Thais Barbosa de Souza, Daniela Miranda Farias, Rozimeri Fatima Coletti, Maria Silvia Oliveira, Carolina Gomes Carrilho, Jorge Aparecido de Barros, Susana Elisa Moreno, Eric Murillo-Rodriguez, Sergio Machado and Andre Barciela Veras*
Affiliation:
- Intercontinental Neuroscience Research Group, Campo Grande,Brazil
Keywords:
Antipsychotic, schizophrenia, bipolar disorder, behaviour, anxiety, stress, open field, elevated plus maze.
Abstract: Background and Objective: Asenapine is an atypical antipsychotic approved by US Food
and Drug Administration in 2009 and by European Medicines Agency in 2010 for Schizophrenia and
Bipolar Disorder treatment. Currently, many studies have been developed in an attempt to clarify and
minimize the risks related to the use of psychotropic during pre/postnatal period on patients with a history
of mental disorders.
Conclusion: The aim of this study was to test the impact of pre and/or postnatal exposition to asenapine
on mice offspring behavior. Four groups of animals, previously treated with a dosage equivalent to
50% of the bioavailability obtained with a 20 mg daily use for human treatment, were exposed to the
Open Field and Elevated plus Maze test. Only the group exposed to asenapine during both pre and
postnatal periods showed response difference in the Elevated Plus Maze test, which was restricted to
urination. However, our data suggest that the administration of asenapine does not induce significant
anxiety-like behaviors in mice.
