Title:A Systematic Review on the Sinomenine Derivatives
Volume: 18
Issue: 11
Author(s): Jian Tang*, Aun Raza, Jian Chen and Huaxi Xu
Affiliation:
- School of Pharmacy, Jiangsu University, Zhenjiang 212013,China
Keywords:
Anti-inflammatory, immunosuppressive, neurodegenerative disorders, sinomenine derivatives, structural modification,
structure-activity relationship.
Abstract: Sinomenine is one of the most widely known alkaloids owing to different therapeutic properties
including anti-inflammatory and immunosuppressive activities, as well as the potency in neurodegenerative
disorders, such as Alzheimer’s disease and Parkinson’s disease. Sinomenine has been
studied as a potential anti-inflammatory agent through appropriate structural modifications. Recently, a
number of such approaches have been attempted in various laboratories with great success. Several series
of derivatives have been synthesized with changes at rings A, B, C and D. Herein, we present an
up to date review of modifications and bioactivities of important modified derivatives. These studies
offer interesting knowledge on the bioactivity and structural specificity of sinomenine, providing better
understanding of the structure-activity relationships (SAR) between designing and development of sinomenine
derivative with better therapeutic and lower side effects.
