Title:Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays
Volume: 25
Issue: 33
Author(s): Lucie Korecká*, Karel Vytřas*Zuzana Bílková
Affiliation:
- Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice,Czech Republic
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Pardubice,Czech Republic
Keywords:
Cancer, diagnosis, biomarker, electrochemical detection, immunosensors, multiplex assay.
Abstract: Cancer is a widespread disease characterized by high mortality. To improve the
survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early
stage is needed. For this reason, there is a continuous push to develop sensitive methods
which can be used in cancer diagnosis. Current diagnosis relies on the quantification of
cancer biomarkers defined as molecules that are measurable in body fluids or tissues and
indicate a change in physiological processes with subsequent pathological manifestations.
This contribution reviews recent developments in the area of electrochemical immunosensors
applicable for the detection of cancer biomarkers that occur in a wide concentration
range including extremely low levels, which are typical for the early stage of the disease.
A summary of various antibody labels used for biomarker analysis and combined with
electrochemical detection is presented. The potential of multiple biomarker analysis, with
its indisputable clinical impact for accurate diagnosis, is also highlighted.
