Title:Novel Functions of MicroRNA-17-92 Cluster in the Endocrine System
Volume: 19
Issue: 2
Author(s): Shan Wan*, Xiang Chen, Yuedong He and Xijie Yu*
Affiliation:
- Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041,China
- Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041,China
Keywords:
miR-17-92 cluster, bone metabolism, glucose homeostasis, dyslipidemia, MicroRNA, endocrine function.
Abstract: Background: MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly
conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates
tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel
functions in the endocrine system.
Objective: To summarize recent findings on the physiological and pathological roles of miR-17-92
cluster in bone, lipid and glucose metabolisms.
Results: MiR-17-92 cluster plays significant regulatory roles in bone development and metabolism
through regulating the differentiation and function of osteoblasts and osteoclasts. In addition, miR-17-
92 cluster is nearly involved in every aspect of lipid metabolism. Last but not the least, the miR-17-92
cluster is closely bound up with pancreatic beta cell function, development of type 1 diabetes and insulin
resistance. However, whether miR-17-92 cluster is involved in the communication among bone,
fat and glucose metabolisms remains unknown.
Conclusion: Growing evidence indicates that miR-17-92 cluster plays significant roles in bone, lipid
and glucose metabolisms through a variety of signaling pathways. Fully understanding its modulating
mechanisms may necessarily facilitate to comprehend the clinical and molecule features of some
metabolic disorders such as osteoporosis, arthrosclerosis and diabetes mellitus. It may provide new
drug targets to prevent and cure these disorders.
