Title:Statins in Aortic Disease
Volume: 23
Issue: 46
Author(s): Vasiliki Tsigkou, Gerasimos Siasos*, Evanthia Bletsa, Maria-Paraskevi Panoilia, Angeliki Papastavrou, Georgios Kokosias, Evangelos Oikonomou, Marina Zaromitidou, Manolis Vavuranakis, Christodoulos Stefanadis and Dimitris Tousoulis
Affiliation:
- Department of Cardiology, ‘Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens,Greece
Keywords:
Aortic disease, cardiovascular diseases, HMG-CoA- inhibitors, inflammation, statins, endothelial dysfunction.
Abstract: Background: Numerous studies indicate that statins have multiple beneficial actions (known as ‘pleiotropic
actions') on cardiovascular system through the improvement of endothelial dysfunction, inflammation,
oxidative stress, excessive arterial thrombosis, and stabilization of the atherosclerotic plaque. Aortic disease primarily
consists of aortic valve stenosis, aortic valve regurgitation, aneurysm disease, and genetic disorders such
as Marfan syndrome, bicuspid aortic valve and aortic coarctation. Many studies have revealed the cardioprotective
actions of statins in aortic disease.
Objective: Our aim was to present current data concerning the value of treatment with statins in aortic diseases.
Methods: A thorough search of PubMed and the Cochrane Database was conducted to identify the studies and
novel articles related to the use of statins in aortic disease.
Results: Numerous studies in animals and humans indicate a beneficial effect of treatment with statins in the
previous conditions apart from a few conflicting data.
Conclusion: There is a need of further investigation in this field, especially for the estimation of the optimal type
and dose of statins required in each clinical condition of aortic disease.
