Title:Research Progress in Reversal of Tumor Multi-drug Resistance via Natural Products
Volume: 17
Issue: 11
Author(s): Qi Guo, Hongyan Cao, Xianghui Qi, Huikai Li, Peizhi Ye, Zhiguo Wang, Danqiao Wang and Mingyu Sun*
Affiliation:
- Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New District, Shanghai 201203,China
Keywords:
Chemotherapeutics, MDR, multi-drug resistance, natural products, tumor, drug.
Abstract: Multidrug resistance occurs when a tumor develops resistance to multiple chemotherapeutic drugs,
which may include antitumor drugs with different chemical structures and mechanisms. Multidrug resistance limits
the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug resistance is
caused by numerous factors including changes in ATP-binding cassette transporters, target proteins, detoxification,
deoxyribonucleic acid repair, drug metabolic enzymes, and signal pathways of apoptosis. Clinical research
indicates that natural products have great potential to treat tumors and reverse multidrug resistance. Natural
products, which often have multiple targets, could play an important role in tumor treatment, have beneficial
effects on tumor inhibition, improve symptoms, reduce radiotherapy and chemotherapy side effects, enhance
immunity, and prolong survival. Because natural products often have few adverse reactions and less drug
resistance, the antitumor activities of natural products have attracted extensive research. We aimed to review the
basic research and clinical application of natural products in the reversal of multidrug resistance.
