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Review Article

咖啡因对神经退行性疾病的保护作用

卷 26, 期 27, 2019

页: [5137 - 5151] 页: 15

弟呕挨: 10.2174/0929867324666171009104040

价格: $65

摘要

背景：最近的研究以及科学界的日益关注，有助于弄清咖啡因的神经健康特性，咖啡因是世界上最消耗的药理活性物质之一。 方法：本文是一篇综述性搜索，以概述咖啡因的神经生化影响的当前状态，重点是该药物有效抵抗多种神经退行性疾病的能力，例如阿尔茨海默氏症，帕金森氏症，亨廷顿氏病，多发性硬化症和肌萎缩性硬化。 结果：本综述中显示的数据收集提供了咖啡因的显着治疗和预防潜力，咖啡因由于其抗氧化活性和多个分子靶点而通过多种途径作用于人脑。但是，由于某些人比其他人对药物更敏感，因此需要根据个人情况调整CF剂量，这可能会限制CF的有效性。 结论：从临床和流行病学研究的复杂性中得出的结果是，CF对所有神经系统疾病都有潜在的显着影响。虽然，仍需要进一步的研究以充分阐明部分仍然难以捉摸的药物作用的几种机制。

关键词: 咖啡因，神经变性，腺苷受体，抗氧化活性，神经保护作用，线粒体生物发生，ALS。

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