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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Protective Effects of the Caffeine Against Neurodegenerative Diseases

Author(s): Ester Tellone*, Antonio Galtieri, Annamaria Russo and Silvana Ficarra

Volume 26, Issue 27, 2019

Page: [5137 - 5151] Pages: 15

DOI: 10.2174/0929867324666171009104040

Price: $65

Abstract

Background: Recent studies and increased interest of the scientific community helped to clarify the neurological health property of caffeine, one of the pharmacologically active substances most consumed in the world.

Methods: This article is a review search to provide an overview on the current state of understanding neurobiochemical impact of caffeine, focusing on the ability of the drug to effectively counteract several neurodegenerative disorders such as Alzheimer’s, Parkinson’s, Huntington’s diseases, Multiple sclerosis and Amyotrophic lateral sclerosis.

Results: Data collection shown in this review provide a significant therapeutic and prophylactic potentiality of caffeine which acts on human brain through several pathways because of its antioxidant activity combined with multiple molecular targets. However, the need to adjust the CF dosage to individuals, because some people are more sensitive to drugs than others, may constituted a limit to the CF effectiveness.

Conclusion: What emerges from the complex of clinical and epidemiological studies is a significant CF potential impact against all neurological disorders. Although, further studies are needed to fully elucidate the several mechanisms of drug action which in part are still elusive.

Keywords: Caffeine, Neurodegeneration, Adenosine receptors, Antioxidant activity, Neuroproective effects, Mitochondrial biogenesis, ALS.

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[http://dx.doi.org/10.1186/s40478-014-0170-2] [PMID: 25492529]

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