Title:Electrochemical MIP-Sensors for Drugs
Volume: 25
Issue: 33
关键词:
仿生传感器，分子印迹聚合物，药物传感器，药物印迹，电聚合，电化学传感器。
摘要: In order to replace bio-macromolecules by stable synthetic materials in separation
techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional
monomers are polymerized together with the target analyte and after template removal
cavities are formed in the ”molecularly imprinted polymer” (MIP) which resemble the active
sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs
were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric
electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance
(SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV)
and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR.
Application of simple electrochemical devices allows both the reproducible preparation of
MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the
whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer
drugs have been presented in literature and tested under laboratory conditions. These
biomimetic sensors typically have measuring ranges covering the lower nano- up to millimolar
concentration range and they are stable under extreme pH and in organic solvents like nonaqueous
extracts.
