Title:Electrochemical MIP-Sensors for Drugs
Volume: 25
Issue: 33
Author(s): Aysu Yarman*, Sevinc Kurbanoglu, Katharina J. Jetzschmann, Sibel A. Ozkan, Ulla Wollenberger and Frieder W. Scheller*
Affiliation:
- Turkish-German University, Faculty of Science, Molecular Biotechnology, Sahinkaya Cad. No. 86, Beykoz, Istanbul 34820,Turkey
- University of Potsdam, Institute of Biochemistry and Biology, Karl-Liebknecht- Strasse 25-26,14476 Potsdam,Germany
Keywords:
Biomimetic sensors, molecularly imprinted polymers, drug sensors, drug imprinting, electropolymerization,
electrochemical sensors.
Abstract: In order to replace bio-macromolecules by stable synthetic materials in separation
techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional
monomers are polymerized together with the target analyte and after template removal
cavities are formed in the ”molecularly imprinted polymer” (MIP) which resemble the active
sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs
were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric
electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance
(SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV)
and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR.
Application of simple electrochemical devices allows both the reproducible preparation of
MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the
whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer
drugs have been presented in literature and tested under laboratory conditions. These
biomimetic sensors typically have measuring ranges covering the lower nano- up to millimolar
concentration range and they are stable under extreme pH and in organic solvents like nonaqueous
extracts.
