Title:Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives
Volume: 18
Issue: 15
Author(s): Mona O. Sarhan, Mohamed A. Motaleb, Ismail T. Ibrahim, Manal M. Anwar* Wafaa. A. Zaghary*
Affiliation:
- Department of Therapeutical Chemistry, National Research Centre, Dokki, Cairo 12622,Egypt
- Department of Pharmaceutical Chemistry, College of Pharmacy, Helwan University, Cairo 11795,Egypt
Keywords:
Anticancer, enzymes, molecular docking, synthetic methods, 1, 3, 5-triazines, anti-protozoals.
Abstract: 1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal
chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects
including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities
have been reported to act by various mechanisms on several molecular targets in human cells such as
methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This
review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer
agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors
active sites. This article also aims to highlight the future directions for the easy access to these
frameworks of more potent and specific anticancer activity.
