Title:The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors
Volume: 12
Issue: 7
Author(s): Chong Hyun Won*, Gyeong-Hun Park, Xunwei Wu, Thanh-Nga Tran, Ki-young Park, Byung-Soon Park, Dong Young Kim, Ohsang Kwon and Kyu-Han Kim*
Affiliation:
- Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2 dong, Songpa-gu, Seoul 138-736,Korea
- Department of Dermatology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744,Korea
Keywords:
Adipose-derived stem cell, alopecia, conditioned media, female pattern hair loss, hair loss, hair regeneration, male
pattern hair loss, mesenchymal stem cell.
Abstract: Background: Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs)
within the stromal vascular fraction of subcutaneous adipose tissue. ADSCs secrete growth factors and
other proteins, and have been used to regenerate skin with satisfactory results.
Objective: This review focuses on the effect of ADSCs and their secretory factors on the stimulation of
hair growth in vitro, ex vivo and in vivo.
Results: The conditioned media of ADSCs (ADSC-CM) increases the proliferation rate of human follicular
cells. ADSCs-derived proteins improve hair growth and protect human dermal papilla cells
against cytotoxic injury caused by androgen and reactive oxygen species. Moreover, ADSC-CM induces
the anagen phase and promotes hair growth in mice, and enhances the elongation of hair shafts in
ex vivo human hair organ cultures.
Conclusion: ADSC-CM promotes hair growth in vitro, ex vivo, and in vivo. Given that ADSCs are one
of the most accessible sources of MSCs, ADSC-derived proteins may be feasible clinical therapeutic
agents for the treatment of hair loss.
