Title:Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica
Volume: 15
Issue: 5
Author(s): Reham Al-Harbi, Mona Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman and Shahenda El-Messery
Affiliation:
- Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah,Saudi Arabia
Keywords:
Antimicrobial activity, pedunculagin, nilocitin, molecular docking, Pimenta dioica, tannins.
Abstract: Background: High rate of bacterial infection potentiates scientists to search natural
products for new antimicrobial agents.
Methods: This research determines the antimicrobial activity of tannins isolated from Pimenta
dioica leaves on Gram-positive and Gram-negative infectious organisms using agar diffusion
method.
Results: All tested compounds were effective against Staphylococcus epidermidis, particularly
pedunculagin and nilocitin exhibited broad spectrum antibacterial effects against tested isolates as
quantified by microtiter plate dilution method.
Conclusion: This will open the era for in-vivo assessment of such compounds for clinical applications.
