Title:Renin-Angiotensin System in Diabetes
Volume: 24
Issue: 9
Author(s): Johannes Rein and Michael Bader*
Affiliation:
- Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin,Germany
Keywords:
Renin-angiotensin system, effector peptide angiotensin, pathogenesis, diabetes mellitus, drugs, therapy.
Abstract: The renin-angiotensin system (RAS) has two different axes, the classical one with the
effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both
peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences,
nephropathy, retinopathy and cardiomyopathy in animal models and patients. In diabetes,
angiotensin II acts mostly deleterious and angiotensin (1-7) protective. In this review we summarize
the knowledge about the role of the different RAS axes in diabetes mellitus and the use of drugs
interfering with the RAS in the therapy of the disease.
