Title:Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders
Volume: 16
Issue: 7
Author(s): David Calderon Guzman, Hugo Juarez Olguin*, Ernestina Hernandez Garcia, Monica Punzo Soto, Mayra Santillan Garcia and Gerardo Barragan Mejia
Affiliation:
- Laboratory of Pharmacology, National Institute of Pediatrics, Av. Iman No.1, 3rd piso, Colonia Cuicuilco. CP. 04530, Mexico City,Mexico
Keywords:
Androgens, antagonist, CNS, neurological disorders, neuroprotectors, steroids.
Abstract: Background & Objective: Multiple classes of natural products, such as antiandrogens or
steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases.
This paper aims to review current knowledge on these substances and their possible relationship
with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive
review of the neurochemical mechanisms of these substances in the central nervous system of
humans and animal models is yet to be undertaken in the literature, particularly regarding their importance
and increasing use.
Conclusion: Androgen receptor antagonists act in a different way that may underlie the benefits of
natural products, with the expectation that in adults, neurological disorders would respond to natural
antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic
roles for natural antiandrogens and steroids in common neurological disorders.
