Title:The Challenge of microRNA as a Biomarker of Epilepsy
Volume: 16
Issue: 1
Author(s): Yihong Ma *
Affiliation:
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto,Japan
Keywords:
Status epilepticus, epileptogenesis, diagnosis, temporal lobe epilepsy, epilepsy, microRNA, therapy.
Abstract: Background: Epilepsy is one of chronic severe neurological disorders possess to recurring
seizures. And now anti-epileptic drugs are only effective in less than one third of epilepsy patients,
and biomarkers predicting are not available when the specific antiepileptic drugs treated.
Advanced studies have showed that miRNA may be a key in the pathogenesis of epilepsy beginning
in the early 2000 years. Several target genes and pathways of miRNA which related to the therapeutic
methods to epilepsy.
Method: We searched PubMed from Jan 1,2000 to Jan 1, 2017, using the terms “epilepsy AND
microRNA AND biomarker” and “seizure AND microRNA AND biomarker”. We selected articles
that featured novel miRNAs in vivo epilepsy models and patients. We then selected the most relevant
articles based on a subjective appraisal of their quality and mechanistic insight that could be
relevant to epilepsy.
Results: Decrease the expression of has-miR134 could be a potential non-invasive biomarker to use
in diagnosis for the epilepsy patients for using hsa-miR-134 also be identified to distinguish patients
with and without epilepsy. miR-181a show significant downregulation in the acute stage, but up
regulation in the chronic stage and in the latent stage there is no changing and how about this phenomenon
appearance in different stage still should be discussed in the future. Besides that, miR-
146a can down-regulated in the patients using genome-wide for serum in circulating miRNAs.miR-
124, miR-199a, and miR-128 etc. could be a candidate for the biomarker in future. miR-15a-5p and
-194-5p down-regulated in epilepsy patients, in the future, it may be used as a novel biomarker for
improve diagnosis.
Conclusion: These observations give a chance that new development for diagnosis and treatment of
epilepsy patients. Advanced technique and miRNA combination may product more effective roles
in epilepsy and other disease. These reports will be available to solve the application of miRNAs as
biomarkers and novel therapy approaches for epilepsy. In summary, researcher who focus on miRNAs
should be understanding of the causes, treatment, and diagnosis of epilepsy. exploration of any
of these effects on the efficacy of these drugs is worthwhile.
