Title:Role of Bradykinin in the Regulation of Endothelial Nitric Oxide Synthase Expression by Cardiovascular Drugs
Volume: 23
Issue: 40
Author(s): Jin Bo Su*
Affiliation:
- Universite Paris-Est Creteil Val-de-Marne, 94700, Creteil,France
Keywords:
Angiotensin-converting enzyme inhibitors, angiotensin-(1-7), AT1 receptor blockers, bradykinin, dihydropyridine calcium channel
blockers, statins, endothelial nitric oxide synthase, nitric oxide, transcriptional and posttranscriptional regulation.
Abstract: NO produced by eNOS plays important roles in the cardiovascular system. Alterations in eNOS activity
and expression occur in various cardiovascular disorders and eNOS constitutes a therapeutic target. In addition
to posttranslational modifications of eNOS that affect eNOS activity, transcriptional and post-transcriptional
regulation of eNOS expression also controls eNOS-derived NO production. Bradykinin is an important determinant
of vascular function and participates in the regulation of eNOS activity and expression. A number of currently
used drugs or investigational molecules targeting specific ion channels, enzymes or receptors, including
dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibitors, statins, AT1 receptor
blockers and angiotensin-(1-7), increase eNOS expression and activity. In this context, activation of bradykinin
B2 receptors appears to be a common step for these drugs to promote eNOS expression, which certainly contributes
to their therapeutic actions.
