Title:Study on Adsorption and Sustained Release of Eucommia ulmoides Oliv. Leaf Extracts on Activated Carbon
Volume: 15
Issue: 2
Author(s): Sheng Zhang*, Xiang-zhou Li and Zhao-yan Zeng
Affiliation:
- College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004,China
Keywords:
Carbon, adsorption, release, Eucommia ulmoides Oliv. leaf, polylactic acid, cytotoxicity.
Abstract: Background: Due to its excellent adsorption capability, activated carbon(AC) has also been
employed as a drug carrier. However, applications of the AC carrier in traditional Chinese medicine
(TCM) have been rare. We selected the Eucommia ulmoides leaf extract as the drug of choice and AC
as its carrier, to investigate the adsorption and sustained release behavior of the Eucommia ulmoides
leaf extract on the AC.
Methods: AC was employed in this study as the sustained release carrier and its capability for adsorption
and sustained release of Eucommia ulmoides leaf extracts was systematically investigated. Acid or
alkali modified AC was assessed for its ability to absorb and sustain release of Eucommia ulmoides leaf
extracts according to a variety of adsorption/release rate and composition.
Results: Results demonstrated that the adsorption rate for the differently modified AC reached above 80
%, whereas the adsorption of Eucommia ulmoides leaf extracts on the AC was selective. The composition
of the sustained release liquid, which was treated by the acid modified AC, was almost similar to
the original extract. The acid modified AC was therefore taken as an optimal carrier that can be used for
Eucommia ulmoides leaf extracts sustained release.
Conclusion: The synchronous release and absorption of different ingredients in the active ingredient
release process ensures the global and cooperative effect with sustained and less toxic advantages. The
ideal synchronous release is that the absorbed component proportion is consistent with its release. The
acid modified AC was therefore taken as the optimal carrier that can be used for Eucommia ulmoides
leaf extracts sustained release.
