Title:Early-phase 18F-AV-45 PET Imaging can Detect Crossed Cerebellar Diaschisis Following Carotid Artery Stenosis and Cerebral Hypoperfusion
Volume: 14
Issue: 3
Author(s): Tsong-Hai Lee, Kuo-Lun Huang, Ting-Yu Chang, Meng-Yang Ho, Shiaw-Pyng Wey, Chia-Ju Hsieh, Tzu-Chen Yen, Kun-Ju Lin*Ing-Tsung Hsiao*
Affiliation:
- Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan,Taiwan
- Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan,Taiwan
Keywords:
Carotid stenosis, positron emission tomography, magnetic resonance imaging, crossed cerebellar diaschisis, carotid
artery stenosis, stroke.
Abstract: Background: Carotid artery stenosis (CAS) may induce cerebral hypoperfusion.
Early-phase 18F-Florbetapir (AV-45/Amyvid, 18F-AV-45) positron emission tomography (PET)
imaging can provide perfusion-like property (pAV-45) for the estimation of cerebral blood flow
(CBF). Supra-tentorial lesions may cause decreased blood flow and metabolism in the contralateral
cerebellum known as crossed cerebellar diaschisis (CCD).
Objective: The aim was to study the occurrence of CCD after CAS using pAV-45 PET.
Methods: Eleven healthy controls and 21 patients with unilateral CAS were studied. All subjects
underwent
18F-AV-45 PET imaging and arterial spin labeling (ASL) CBF magnetic resonance
perfusion imaging. The pAV-45 and ASL CBF values were first correlated. Then, cerebral and
cerebellar hypoperfusion volume was analyzed. The cerebral and cerebellar perfusion asymmetry
indices (AIs) were calculated from the pAV-45 standard uptake value ratios (SUVRs) of bilateral
cerebral and cerebellar cortices, respectively.
Results: We found that pAV-45 SUVR was significantly correlated to ASL CBF (p<0.0001,
r=0.5731). The AI of cerebellar perfusion was negatively correlated to that of cerebral perfusion
(p<0.0001, r=-0.8751). Multiple linear regression showed the cerebral AI (p<0.0001) and hypoperfusion
volume (p=0.02) but not the infarction severity and CAS degree significantly correlated to
cerebellar AI. If the lower limit of 95% confidence interval of cerebellar AI in healthy controls was
set as cut-off for positive CCD, the occurrence of CCD correlated to infarction severity in CAS
patients (p=0.03).
Conclusion: Our results suggest pAV-45 is reliable to study CBF change. Under unilateral CAS,
cerebral AI and hypoperfusion severity may determine the occurrence of CCD.
