Title:Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases
Volume: 18
Issue: 12
Author(s): Junwei Ma, Yibin Wang, Zhong Wang, Haiying Li, Zhimin Wang*Gang Chen*
Affiliation:
- Suzhou Kowloon Hospital affiliated Shanghai Jiaotong University Medical School, Suzhou, Jiangsu Province,China
- Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006,China
Keywords:
Drug-induced therapeutic hypothermia, neuroprotection, cerebrovascular diseases, cerebral hemorrhage, cerebral
ischemia.
Abstract: Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia
in cerebrovascular diseases and discusses its related side effects.
Method: A systematic literature search was performed using Pubmed and Embase electronic databases
for a retrospective analysis.
Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage
and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits.
Therefore, drug-induced hypothermia has an important research value and is worth further consideration
in the clinical setting. However, drug-induced hypothermia is also associated with side effects,
such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte
imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with
cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3)
opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6)
thyroid drugs; (7) adenosine drugs; and (8) purine drugs.
