Title:Biosensors for Screening Kinase Inhibitors
Volume: 17
Issue: 22
Author(s): Nikhil Bhalla*Pedro Estrela
Affiliation:
- Okinawa Institute of Science and Technology Graduate University (OIST) 1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0412,Japan
Keywords:
Biosensors, Screening Kinase Inhibitors, protein phosphorylation, cancer, drug discovery.
Abstract: For successful drug discovery it is important to understand the fundamentals of the underlying
causes and consequences of the diseases for which the drug is being developed. One such physiological
process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification
of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various
cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling
or curing these diseases by reducing protein phosphorylation. This review discusses the technologies
capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors
of protein kinases.
