Title:Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents
Volume: 24
Issue: 26
Author(s): Shalini Nekkanti , Ramya Tokala and Nagula Shankaraiah *
Affiliation:
- Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037,India
Keywords:
Anticancer, distamycin derivatives, DNA minor groove, pyrrolo[2, 1-c][1, 4]benzodiazepines, small
molecules, β-carboline.
Abstract: Agents which can recognize and bind specific sequences of DNA offer selective
therapy through the modulation of specific transcription factors or genes. Recently,
there has been renewed interest in the field of anticancer minor groove binders. This may
be attributed to the fact that many compounds of this class have demonstrated significant
antitumor activity against a wide variety of cancers in recent clinical trials. This review
will discuss the recent efforts to overcome the drawbacks of existing minor groove binding
anticancer agents through rational drug design based on scaffolds with known antitumor
activity.
