Title:Polypharmacology of Aconitum and Delphinium sp. Diterpene Alka loids: Antiarrhythmic, Analgesic and Anti-Inflammatory Effects
Volume: 14
Issue: 4
Author(s): Florbela Pereira*
Affiliation:
- Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829- 516 Caparica,Portugal
Keywords:
Diterpene alkaloids, Aconitum, Delphinium sp., antiarrhythmic activity, analgesic activity, anti-inflammatory activity.
Abstract: Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium
sp. has been extensively studied. From 1998 to 2014, more than 400 new diterpene alkaloids
were isolated from Nature. Pharmacological researches have indicated that many diterpenoid alkaloids
are the main bioactive components which have arrhythmogenic, local anesthetic, antiarrhythmic, curariform,
analgesic, hypotensive, anti-inflammatory, anti-microbial, anti-tumor, spasmolytic, neurotropic
and psychotropic activities. In the present review, the antiarrhythmic, analgesic and anti-inflammatory
activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. Moreover,
their Structure-Activity Relationship was also analyzed.
