Title:Differences in Relative Levels of 88 microRNAs in Various Regions of the Normal Adult Human Brain
Volume: 6
Issue: 2
Author(s): Elena V. Filatova*, Anelya Alieva, Maria I. Shadrina and Petr A. Slominsky
Affiliation:
- Institute of Molecular Genetics RAS, Moscow,Russian Federation
Keywords:
Brain, cluster analysis, expression, human, microRNA, normal brain tissues.
Abstract: Aim of Study: Since the discovery of microRNAs (miRNAs) in the 1990s, our knowledge
about their biology has grown considerably. The increasing number of studies addressing the role of
miRNAs in development and in various diseases emphasizes the need for a comprehensive catalogue
of accurate sequence, expression and conservation information regarding the large number of miRNAs
proposed recently in all organs and tissues. The objective of this study was to provide data on the levels
of miRNA expression in 15 tissues of the normal human brain.
Materials and Methods: We conducted an analysis of the relative levels of 88 of the most abundantly
expressed and best characterized miRNA derived postmortem from well-characterized samples of
various regions of the brains from five normal individuals.
Results: The cluster analysis revealed some differences in the relative levels of these miRNAs among
the brain regions studied. Such diversity can be explained by different functioning of these brain regions.
Conclusion: We hope that the data from the current study are a resource that will be useful to our colleagues
in this exciting field, as more hypotheses will be generated and tested with regard to small
noncoding RNA in the human brain in healthy and disease states.
