Title:PPARs in Neurodegenerative and Neuroinflammatory Pathways
Volume: 15
Issue: 4
Author(s): E. Benedetti, L. Cristiano, A. Antonosante, M. d'Angelo, B. d'Angelo, S. Selli, V. Castelli, R. Ippoliti, A. Giordano and A. Cimini*
Affiliation:
- National Institute for Nuclear Physics (INFN), Gran Sasso National Laboratory (LNGS), Assergi,Italy
Keywords:
Neurodegenetic disease, immune system, microglia cells, cytokines, neuroinflammation, neurons.
Abstract: Background: PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly
fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content
and has the higher energetic metabolism in the body.
Methods: In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is
observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a
complicated relationship between the innate immune response and tissue metabolism.
Results: In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly
involving glucose utilization and production, a condition which is generally related to metabolic changes.
Conclusion: Taking into account the high expression of PPARs in the brain, this review will focus on the
role of these transcription factors in CNS diseases.
