Title:Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease
Volume: 24
Issue: 25
Author(s): Juan M. Salas , Ana B. Caballero *, Ginés M. Esteban-Parra and José M. Méndez-Arriaga
Affiliation:
- Department of Inorganic and Organic Chemistry (Inorganic Chemistry Section), University of Barcelona, Martí i Franquès 1–11, 08028 Barcelona,Spain
Keywords:
Triazolopyrimidine, metal complexes, Leishmania, Trypanosoma cruzi, leishmaniasis, Chagas disease,
neglected tropical diseases.
Abstract: Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5-
a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy
to agriculture or even photography. Their similarity to purines confers a potential
bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal,
antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties.
In this review, we focus on the compounds that these nitrogen heterocycles form with
metal ions and their antiparasitic activity and therapeutic potential against two neglected
diseases of tropical prevalence, leishmaniasis and Chagas disease.
