Title:Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy
Volume: 19
Issue: 2
Author(s): Afshin Babazadeh, Mahdi Zeinali and Hamed Hamishehkar*
Affiliation:
- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Cancer, drug delivery, nanocarrier, phospholipid, phytosome, anticancer agent.
Abstract: Background: Cancer is one of the main causes of death in the world. It has not yet been
cured in an efficient manner and has remained a major challenge for current chemotherapy.
Objective: This review summarizes the latest investigations regarding the possible application of phytosome
complexes for cancer therapy, their formulation techniques, and mechanism of transportation
through phytosome.
Results: Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties
of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer
agents to the site of action. The greater stability of nanophytosomes is due to formation of chemical
links between phospholipid molecules and phytoactive agents. Among several new drug delivery systems,
phytosomes depict an advanced technology to deliver phytoactive compounds to the target site
of action, and at present, several phytosome formulations are in clinical use.
Conclusion: Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.
