Title:Current Drug Design Strategies for Fighting Against Swine Influenza
Volume: 12
Issue: 2
Author(s): Muneer Alam*Sisir Nandi
Affiliation:
- Division of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research, Affiliated to Uttarakhand Technical University, Kashipur-244713,India
Keywords:
H1N1 swine influenza A, QSAR, pharmacophore, structure based screening, molecular
docking.
Abstract: Background: Swine influenza is a seasonal health threat due to global
outbreak of H1N1 pandemic in 2009 leading to death of millions of people because of
antigenic drift of the dangerous influenza A viral strains. Scarcity of specific chemotherapeutics
emphasizes the priority of drug design and discovery of new anti-influenza leads
having less toxicity and resistant to the dynamic viral strains.
Objective: The present review is an update in the current trends in drug design from the
stand point of ligand and structure based screening of potent swine influenza inhibitors.
Method: In quest of different drug targets, ligand and structure based chemometric
screening tools are the major platform for the design of potent chemotherapeutics having
greater affinity towards various targets including polymerase basic protein 1 (PB1), PB1-
F2, PB2, polymerase acidic protein (PA), surface glycoproteins hemagglutinin and
neuraminidase, nucleocapsid protein (NP), nuclear matrix proteins including M1, Ion pore
protein—M2 as well as two nonstructural proteins NS1 and NS2, respectively.
Results: Ligand based screening deals with QSAR and pharmacophore modeling whereas
structure based virtual screening deal with crystallography and molecular docking.
Conclusion: The study in this direction can increase the search of hit rates and decrease
in cost of drug design and development prior to experiment by producing potent chemotherapeutics
against swine influenza.
