Title:A Therapeutic Target of Cerebral Hemorrhagic Stroke: Matrix Metalloproteinase- 9
Volume: 18
Issue: 12
Author(s): Baoqi Dang, Xiaochun Duan, Zhong Wang, Weichun He*Gang Chen*
Affiliation:
- Department of Neurosurgery, Zhangjiagang Hospital of Traditional Chinese Medicine, Soochow University, Suzhou, Jiangsu Province,China
- Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province,China
Keywords:
Matrix metalloproteinase-9, intracerebral hemorrhage, subarachnoid hemorrhage, hemorrhagic transformation,
brain injury.
Abstract: Background: Cerebral hemorrhagic stroke, including intracerebral hemorrhage (ICH), subarachnoid
hemorrhage (SAH), and hemorrhagic transformation after cerebral infarction, is a major
medical emergency in the neurology, neurosurgery, emergency and other clinical departments. The
pathophysiological mechanisms of these cerebral hemorrhagic diseases have not been fully elucidated,
and there are no effective pharmacological and molecular treatments against these diseases. Matrix
metalloproteinase-9 (MMP-9), also known as collagenase B, is one of the most important members of
the matrix metalloproteinases (MMPs) family.
Objective: This article reviews the role of MMP-9 in the pathogenesis of diseases such as brain hemorrhage,
hemorrhagic transformation after cerebral infarction, SAH, and brain injury.
Results: The expression levels of MMP-9 in brain tissue increased after cerebral hemorrhage and related
to the prognosis of brain hemorrhage. MMP-9 is related to post-thrombolytic hemorrhagic transformation
after cerebral infarction. Inhibition of MMP-9 can reduce secondary brain injury after brain
hemorrhage. MMP-9 aggravates the early brain injury and cerebral vasospasm after SAH.
Conclusion: MMP-9 is involved in the pathological process of hemorrhagic stroke through a variety
of mechanisms and is closely related to prognosis after cerebral hemorrhagic stroke.
