Title:Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review
Volume: 25
Issue: 14
Author(s): David Feldman, Elizabeth Leahy and Seong-Ho Lee *
Affiliation:
- Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742,United States
Keywords:
Angiogenesis, apoptosis, growth arrest, mechanism, metastasis, tolfenamic acid.
Abstract: Tolfenamic acid is one of the conventional non-steroidal anti-inflammatory
drugs (NSAIDs) commonly used for the treatment of inflammation, migraines and pain.
There has been a growing body of experimental evidence that tolfenamic acid possesses
anti-cancer activity. However, in order to develop a therapeutic strategy using tolfenamic
acid for the treatment of cancer, further research is required to highlight reliable cellular
and molecular mechanisms of anti-cancer properties. Tolfenamic acid has been shown to
alter the expression of several genes that represent cancer hallmarks including apoptosis,
growth arrest, angiogenesis and metastasis. Recently, a couple of research groups including
ours reported that tolfenamic acid targets multiple oncogenic or tumor suppressive
signaling pathways in various types of cancer models. Here, we highlight multiple molecular
targets responsible for the anti-cancer mechanism of tolfenamic acid and the benefits
of combinational use of this drug with other anti-cancer drugs.
