Title:Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia
Volume: 18
Issue: 10
关键词:
先兆子痫，非编码RNA，LncRNA，滋养层，胎盘，发病机制
摘要: Background: Preeclampsia, a gestational disease characterized by hypertension and proteinuria
twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although
multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic
pathways remain largely undefined. The placenta plays a critical role in the fetal development by
carrying out the barrier, fetal-maternal exchange, and endocrine functions during pregnancy. Accumulated
data indicated that the expression of multiple long noncoding RNA (LncRNA) is dysregulated in
preeclamptic placentas. Moreover, manipulation of LncRNA expression led to functional alterations in
trophoblast cell cultures, including changes in proliferation, differentiation, apoptosis, and migration.
Objective: This article reviews published data on this subject and provides detailed information on the
regulation and function of LncRNAs IGF2/H19, MEG3, SPRY4-IT1, HOTAIR, MALAT1, and
FLT1P1 and CEACAMP8 in placental trophoblasts. The potential mechanisms underlying the action
of these LncRNAs are also discussed to facilitate a better understanding on the potential role of these
LncRNAs for the pathogenesis of preeclampsia.
Conclusion: It is elaborated that some lncRNAs probably contribute to the pathogenesis of
preeclampsia through methylation, Notch-EGFL7 signaling pathway and Wnt/β-catenin pathway.
