Title:The Cross-talk between Tristetraprolin and Cytokines in Cancer
Volume: 17
Issue: 11
Author(s): Jian Guo, Hao Wang, Shiyi Jiang, Jiazeng Xia *Shimao Jin *
Affiliation:
- Department of General Surgery and Translational Medicine Center, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, 214002,China
- Department of General Surgery and Translational Medicine Center, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, 214002,China
Keywords:
Cytokine, TTP, cross-regulation, cancer, ARE, post-transcription.
Abstract: Cytokines are small secreted proteins serving as vital mediators that mediate the host immune
responses. Transcription and post-transcription play a critical role in cytokine expression through the regulation
of message RNA (mRNA) cytoplasmic localization, translation initiation and decay. Researches have been
conducted to reveal regulatory mechanisms of cytokines production in cells involved in cancer. AU-rich element
(ARE) can regulate the degradation and translation of mRNA by connecting with specific ARE binding
proteins. It is now clear that tristetraprolin (TTP), as the most common ARE binding protein, negatively
regulates many aspects of the cytokines through binding to the AREs in the 3'-untranslated region (3'UTR) of
mRNA. Furthermore, some certain cytokines have an impact on TTP expression and function. Therefore, the
cross-regulation between cytokines and TTP has come into sight. The complicated regulatory networks between
cytokines and TTP are closely related to tumorigenesis. In this review, we summarize specific regulatory
mechanisms of cytokine mRNAs. We focus on how TTP negatively regulates inflammatory and oncogenic
cytokines expression after combining with AREs, we also pay attention to some cytokines mediating the expression
of TTP and their cross-talk in various cancers in detail.
