Title:Heterocyclic Analogues as Kinase Inhibitors: A Focus Review
Volume: 17
Issue: 22
Author(s): Vikas Sharma, Raj Kamal and Vipin Kumar*
Affiliation:
- Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer-305801, Rajasthan,India
Keywords:
Kinase, imatinib, heterocyclic, inhibitor, moieties, sorafexib
Abstract: Role of kinase inhibitors in various diseases is well established and discovery of imatinib
opens up new paradigms in kinase inhibition. Furthermore, presence of heterocyclic moiety in a kinase
inhibitor seems to be essential now. However, the potential of a single heterocyclic moiety was
discussed in variety of reviews but a focus review considering the potential of different heterocyclic
moieties is unavailable. Based on this, we classify prospective kinase inhibitors on the basis of number
of heterocyclic moieties present and summarize the prospective kinase inhibitors. Finally, important
key points, current challenges and future prospects of kinase inhibitors are also discussed.
