Title:Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery
Volume: 17
Issue: 22
Author(s): Nameet Kaur, Arun K. Sharma, Adeeba Shakeel, Vipin Kumar, Aarti Singh, Apoorv Gupta, Deepa Suhag, Satyendra K. Rajput*Monalisa Mukherjee*
Affiliation:
- Pharmacology and Toxicology, Amity Institute of Pharmacy, Amity University-Uttar Pardesh, Sector- 125, Noida, Uttar Pradesh,India
- Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, NOIDA, Uttar Pradesh, Sector-125, Noida, Uttar Pradesh,India
Keywords:
Superoxide dismutase, kinase, oxidative stress, click chemistry, gene modulation, nano-formulation.
Abstract: In recent years, several scientific investigations have reported the therapeutic implications
of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical
trials. Indeed, various kinase, molecular signaling and physiological process has altered by
reactive oxygen species. In spite of the abundant available literature reports, patents, clinical trials and
commercialized products, the therapeutic application of SOD as a potential drug still remains unclear.
Owing to the technical challenges associated with the utilization of SOD as a drug, we revisited the
structural arrangement and cellular signaling, significant association with kinase, exploring the new
target sites and introducing new formulation strategies such as gene modulation, nano-formulations
and click chemistry is a prerequisite. In-addition to gene modulation strategies, encapsulated formulation
within a nano-carrier for producing promising SOD therapeutic effects, application of click
chemistry including bioconjugation and cyclo-addition are the most prominent methods to produce
highly efficient SOD formulations. Thus, the present review enlightens the foremost technique which
may have better interaction with kinase and other cellular signaling for regulating the physiological
process.
