Title:The Hot and Potential Targets of Type 2 Diabetes Mellitus Treatment in Recent Decade
Volume: 19
Issue: 1
Author(s): Qi Xu, Lijun Wang, Jiao Luo and Dayong Shi*
Affiliation:
- Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao,China
Keywords:
Type 2 diabetes mellitus, insulin resistance, insulin secretion, targets, mechanism, drugs.
Abstract: Background: Type 2 diabetes mellitus (T2DM) has been a great burden to the world and it
is urgent to develop new treatment strategies. Recently, many targets are currently available to aid in
the drug discovery of this disease as our understanding of the pathophysiology of T2DM develops.
Objective: This article is intended to provide a broad ranging overview of 14 prominent molecule targets
being pursued for the treatment of diabetes in recent decade, with regard to their therapeutic rationale,
small molecule modulators and application prospects.
Result: These targets are roughly divided into three general areas that correlate with insulin secretion,
act on the insulin sensitivity, and have an effect on the complications, and these three kinds of targets
are all helpful for the treatment of T2DM. Considering the fact that the lack of insulin become the
main problem with the progress of T2DM, these targets based on insulin secretion would be more
promising.
Conclusion: Most of these new and potential targets mentioned in article lack clinical data and may or
may not come to fruition for the treatment of diabetes in the future. Hence, further studies will illuminate
the potential for each drug targets, although it is clear that this will take a lot of time.
