Title:Curcumin: Not So Spicy After All
Volume: 17
Issue: 15
Author(s): Amitabh Jha*, Prabhu. P. Mohapatra, Salma A. AlHarbi and Nusrat Jahan
Affiliation:
- Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6,Canada
Keywords:
Anticancer, antioxidant, curcumin analogs, curcumin, diarylheptanoids, diarylpentanoids, formulations, mechanism
of action, Michael acceptor, pharmacokinetics, topoisomerase IIα inhibitors.
Abstract: Background: This is a short review on the most recent studies on curcumin and its analogs,
including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself
reported in the recent years are reviewed. Although curcumin has shown great potential in treating various
diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
Method: The recent methods developed to solve this problem are briefly described.
Conclusion: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and
diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented.
