Title:Structural Exploration of Synthetic Chromones as Selective MAO-B Inhibitors: A Mini Review
Volume: 20
Issue: 6
Author(s): Bijo Mathew*, Githa Elizabeth Mathew, Jacobus P. Petzer and Anel Petzer
Affiliation:
- Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad 678557, Kerala,India
Keywords:
Monoamine oxidase, chromone, coumarin, chalcone, reversible inhibition, Parkinson's disease.
Abstract: Aim and Objective: Specific inhibitors of monoamine oxidase (MAO)-B are considered
useful therapeutic agents in targeting neurological disorders like Alzheimer's and Parkinson's
diseases. Due to the academic challenge of designing new hMAO-B inhibitors and the possibility of
discovering compounds with improved properties compared to existing MAO-B inhibitors, a number
of research groups are searching for new classes of chemical compounds that may act as selective
hMAO-B inhibitors.
Materials and Methods: Among these, chromone (4H-1-benzopyran-4-one) derivatives have
recently emerged as a chemotype with specific and high potency MAO-B inhibition. Chromones are
structurally related to a series of coumarins and chalcones, which are well-known inhibitors of
MAO-B.
Results: The experimental evidence has demonstrated that most of the chromone skeleton derived
compounds have shown potent, reversible and selective type of hMAO-B inhibitors.
Conclusion: The current review focuses on the MAO-B inhibitory properties of various synthetically
derived chromones with specific emphasis on the structure-activity relationships and molecular
recognition of MAO-B inhibition by this class. This review covers the recent updates present in the
literature and will certainly provide a greater insight for the design and development of new class of
potent chromone based selective MAO-B inhibitors.
