Title:A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
Volume: 3
Issue: 3
Author(s): Diego M. Ruiz, Juan C. Autino and Gustavo P. Romanelli*
Affiliation:
- Centro de Investigación en Sanidad Vegetal (CISaV), Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata, Calles 60 y 119, B1904AAN La Plata, Buenos Aires,Argentina
Keywords:
Dihydroangelicins, dihydrofurocoumarins, microwave radiation, green chemistry, heteropolyacid, Preyssler structure.
Abstract: Background: Dihydrofurocoumarins are a large family of compounds, among them, dihydroangelicins
and dihydropsoralens, are present in various plant species with varied biological activity.
Several strategies have been developed for synthesizing these compounds and various catalysts
have been used for this purpose.
Methods: In this work, we report the synthesis of 8,9-dihydrofuran [2, 3-h] coumarins using allyloxycoumarin
cycloaddition in sustainable conditions: absence of solvents, application of microwave
radiation, and insoluble acid catalysis by means of heteropolyacids with Preyssler structure,
[H14(NaP5MoW29O110)].
Conclusion: With these conditions, and testing sustainability by means of Eco-Scale and E-factor, we
replace the use of solvents and mineral acids having a great impact on the environment with a solid,
easily recoverable heteropolyacid.
