Title: Membrane Receptors for Vitamin D Steroid Hormones: Potential NewDrug Targets
Volume: 4
Issue: 1
Author(s): M. C. Farach-Carson and I. Nemere
Affiliation:
Keywords:
Vitamin D, Steroid, Hormones, Osteoclasts, immunohistochemical, 1,25D3-MARRS
Abstract: There is increasing evidence that steroid hormones derived from vitamin D act through classical nuclear receptors (nVDR), as well as specific binding sites on the plasma membrane of target cells that are coupled to signal transduction systems. These sites are referred to as M embrane A ssociated, R apid R esponse S teroid (MARRS) binding proteins or complexes. In the case of the seco-steroid 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the two
