Title:A Review of Ruthenium Complexes Activities on Breast Cancer Cells
Volume: 17
Issue: 15
Author(s): Cecília P. Popolin and Márcia R. Cominetti*
Affiliation:
- Departamento de Gerontologia, Universidade Federal de São Carlos. Rod. Washington Luis, Km 235, São Carlos, SP, 13565-905,Brazil
Keywords:
Apoptosis, breast cancer, metastasis, migration, proliferation, ruthenium complexes.
Abstract: Background: Cancer is one of the main causes of death worldwide. Breast cancer is the
most prevalent type of cancer in women and the leading cause of cancer deaths due to its high metastasis
to the lymph nodes, lungs bones and brain. Interactions with the stromal microenvironment surrounding
tumor cells facilitate tumor cell migration and invasion of tissues and dissemination to other organs, to
form metastasis. The development of antitumor metal-based drugs was originated with the discovery of
cisplatin, however, its severe side effects represent a limitation for its clinical use. Ruthenium (Ru) complexes
with different ligands have been successfully studied as promising antitumor drugs.
Conclusion: In this review, we focused on the effects of Ru complexes on breast cancer cells and their
impact on different steps of the metastatic process.
