Title:Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016
Volume: 18
Issue: 3
Author(s): Gita Chawla*, Baby Naaz and Anees A. Siddiqui
Affiliation:
- Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062,India
Keywords:
Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.
Abstract: 1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities
and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4-
oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory
and analgesic activities with reduced adverse effects. The purpose of this review is to compile the
reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The
review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten
years.
