Title:Cytochrome P450 Structure, Function and Clinical Significance: A Review
Volume: 19
Issue: 1
Author(s): Palrasu Manikandan and Siddavaram Nagini*
Affiliation:
- Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002, Tamil Nadu,India
Keywords:
Adverse drug reactions (ADRs), cytochrome P450, drug interactions, genetic polymorphisms, microRNA, moonlighting
proteins, xenobiotics.
Abstract: Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction
or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions.
CYP enzymes can be transcriptionally activated by various xenobiotics and endogenous substrates
through receptor-dependent mechanisms. CYP enzyme inhibition is a principal mechanism for metabolism-
based drug-drug interactions. Many chemotherapeutic drugs can cause drug interactions due
to their ability to either inhibit or induce the CYP enzyme system. Predictions based on in silico
analyses followed by validation have identified several microRNAs that regulate CYPs. Genetic polymorphisms
and epigenetic changes in CYP genes may be responsible for inter-individual and interethnic
variations in disease susceptibility and the therapeutic efficacy of drugs.
Objective: The present review is a comprehensive compilation of cytochrome P450 structure, function,
pharmacogenetics, pharmacoepigenetics and clinical significance.
Conclusion: Knowledge about the substrates, inducers, and inhibitors of CYP isoforms, as well as the
polymorphisms of CYP enzymes may be used as an aid by clinicians to determine therapeutic strategy,
and treatment doses for drugs that are metabolized by CYP gene products.
