Title:microRNAs-based Predictor Factor in Patients with Migraine-ischemic Stroke
Volume: 6
Issue: 1
Author(s): Luca Gallelli, Antonio Siniscalchi*, Marco Carotenuto, Maria C. Caroleo, Erika Cione and Vincenzo Guidetti
Affiliation:
- Department of Neurology, Annunziata Hospital Via F. Migliori, 1; 87100 Cosenza,Italy
Keywords:
Cerebral infarct, cerebrovascular diseases, microRNA, migraine, neurological diseases, pathophysiology.
Abstract: Among the clinical spectrum of neurological diseases, migraine is often associated with
cerebro-vasculopathy. Impairment of neuroimmune mediators in the central nervous system has been
recognized in the pathophysiology of migraine-related stroke. Although genetic correlation was found
in patients with migraine-related stroke, the epidemiology of this disease indicates a need in biomarker
searching discovery and validation. In this view, small molecule, called microRNAs (miRNAs), able
to regulate immune and neuronal processes has been reported in patients with migraine and ischemic
stroke and unambiguous miRNAs related to these diseases could be established as new molecular indicator
of precocity for clinical and/or pharmacological intervention. Therefore, further exploration of
this area is necessary, as greater understanding of these biomarkers could reveal the common mechanisms
involved in the pathophysiology of migraine in patients with cerebral infarct.
