Title:In silico Analysis of Toxins of Staphylococcus aureus for Validating Putative Drug Targets
Volume: 17
Issue: 2
Author(s): Ramadevi Mohana and Subhashree Venugopal*
Affiliation:
- Department of Integrative Biology, VIT University, Vellore-632014, Tamil Nadu,India
Keywords:
Staphylococcus aureus toxins, in silico analysis, drug target validation, BLAST, interactome
analysis.
Abstract: Toxins are one among the numerous virulence factors produced by the
bacteria. These are powerful poisonous substances enabling the bacteria to encounter
the defense mechanism of human body. The pathogenic system of Staphylococcus
aureus is evolved with various exotoxins that cause detrimental effects on human
immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and
γ-hemolysin were downloaded from Uniprot database and were analyzed to
understand the nature of the toxins and for drug target validation. The results inferred
that the toxins were found to interact with many protein partners and no homologous
sequences for human proteome were found, and based on similarity search in
Drugbank, the targets were identified as novel drug targets.
