Title:Overview of the Structure and Function of Protein Kinases
Volume: 13
Issue: 2
Author(s): Sugunadevi Sakkiah, Guang Ping Cao, Staya P. Gupta and Keun Woo Lee*
Affiliation:
- Division of Applied Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828 Republic of Korea and Department of Internal Medicine, College of Medicine, Busan Paik Hospital, Inje University, Gimhae,Korea
Keywords:
AGC, CaMK, CMGC, protein kinases, tyrosine kinase.
Abstract: After G protein-coupled (GPC) receptors, protein kinases are considered as most important
drug targets. Kinase family consists of multigene, which is particularly relevant to various diseases.
Protein phosphorylation by kinases plays a crucial activity in many cellular processes like apoptosis,
cell division, survival, metabolism, etc. The emergence of various protein kinases crystal structures
from many research groups gives a deep insight to understand the catalysis and regulation of different
protein kinases. This review will mainly focus on the active site structures and functions of few
kinases related to different families such as Protein A, G, and C kinase family (AGC),
Ca2+/Calmodulin-dependent kinase family (CaMK), Cyclin-dependent kinase family (CMGC), Receptor
guanylatecyclase family (RGC), Tyrosine kinase family (TK), Tyrosine kinase-like family (TKL),
Sterile 20 Serine/threonine kinase family (STE), and Casein kinase 1 family (CK1).
