Title:Recent Advances in Targeted Therapy for Glioma
Volume: 24
Issue: 13
关键词:
神经胶质瘤、临床试验、靶向治疗、细胞信号转导通路、神经胶质瘤干细胞、免疫治疗。
摘要: Gliomas are the most common primary malignant brain tumors, which have a universally
fatal outcome. Current standard treatment for glioma patients is surgical removal followed
by radiotherapy and adjuvant chemotherapy. Due to therapeutic resistance and tumor
recurrence, efforts are ongoing to identify the molecules that are fundamental to regulate the
tumor progression and provide additional methods for individual treatment of glioma patients.
By studying the initiation and maintenance of glioma, studies focused on the targets of tyrosine
kinase receptors including EGFR, PDGFR and other crucial signal pathways such as
PI3K/AKT and RAS/RAF/MAPK pathway. Furthermore, recent advances in targeting immunotherapy
and stem cell therapy also brought numerous strategies to glioma treatment. This
article reviewed the researches focused on the advanced strategies of various target therapies
for improving the glioma treatment efficacy, and discussed the challenges and future directions
for glioma therapy.
