Title:Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases
Volume: 16
Issue: 10
Author(s): Q. Nie, X.-D. Gong, M. Liu and D. W.-C. Li
Affiliation:
Keywords:
PTM, phosphorylation, sumoylation, protein functions.
Abstract: Post-translational modifications (PTMs) such as phosphorylation,
acetylation, methylation, ubiquitylation, sumoylation are important
mechanisms to regulate functions of different proteins. Among various
PTMs, phosphorylation, discovered about 60 years ago, is probably the
most common modification. In contrast, sumoylation, identified about two
decades ago is emerging as a key regulatory mechanism modulating protein
functions. Although studies on protein phosphorylation and sumoylation
have been extensively reviewed, much less attention has been paid to their
cross-talk and their co-regulation of the same protein target. Here we
summarize various examples of the cross-talks between protein
phosphorylation and sumoylation, and discuss their functions in regulating normal physiology
and pathogenesis.
